期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 44, 页码 11124-11130出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2820-08.2008
关键词
executive function; cognitive flexibility; reversal learning; set shifting; Wisconsin Card Sorting Test; behavior
资金
- University of Maryland Intramural Program (E.M.P.)
- National Alliance for Research on Schizophrenia
- Depression Young Investigator Award
- Autism-Speaks Predoctoral Fellowship
- National Institutes of Health [R01 AG027097, R01 DA018826, R56 MH57683]
Many neuropsychiatric diseases are associated with cognitive rigidity linked to prefrontal dysfunction. For example, schizophrenia and Parkinson's disease are associated with performance deficits on the Wisconsin Card Sorting Test, which evaluates attentional set shifting. Although the genetic underpinnings of these disorders can be reproduced in mice, there are few models for testing the functional consequences. Here, we demonstrate that an analog of the Wisconsin Card Sorting Test, developed in marmosets and recently adapted to rats, is a behavioral model of prefrontal function in mice. Systematic analysis demonstrated that formation of the attentional set in mice is dependent on the number of problem sets. We found that mice, like rats and primates, exhibit both affective and attentional sets, and these functions are disrupted by neurotoxic damage to orbitofrontal and medial prefrontal cortical areas, respectively. These data are identical to studies in rats and similar to the deficits reported after prefrontal damage in a comparable task in marmosets. These results provide a behavioral model to assess prefrontal function in mice.
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