期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 51, 页码 13995-13999出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4645-08.2008
关键词
zinc; barrel cortex; cortical plasticity; enrichment; somatosensory cortex; synaptic plasticity
资金
- Natural Sciences and Engineering and Research Council of Canada
- graduate scholarship
Despite the plethora of reports that demonstrate plasticity in the mammalian cerebral cortex, the characterization of the cellular mechanisms that mediate it is sparse. Here, we show that the magnitude of the experience-dependent regulation of vesicular zinc is significantly increased through enriched-environment housing. Mice were reared either in a deprived environment and subsequently housed in deprived, minimally enriched, or enriched conditions after the removal of the c-row of vibrissae or reared in an enriched environment before and after vibrissae removal. Levels of vesicular zinc were assessed in deprived and nondeprived barrels 6 h to 14 d after vibrissae removal. We found that housing in enriched environmental conditions resulted in a greater change in vesicular zinc levels than did other housing conditions; however, this effect was dependent on both the magnitude and duration of enrichment. Our data indicate that enriched-environment housing has profound effects on the regulation of vesicular zinc that occurs concurrently with experience-dependent plasticity, suggesting a role for zinc in the multitude of cortical modifications associated with enriched environments.
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