期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 46, 页码 12120-12124出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2509-08.2008
关键词
cytoskeleton; hippocampus; plasticity; synapse; neurotrophin; synaptic plasticity
资金
- National Institutes of Health [GM083889, AG029596]
- National Science Foundation [0548543]
- March of Dimes Foundation [1-FY04-107]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0548543] Funding Source: National Science Foundation
It is generally believed that only the actin cytoskeleton resides in dendritic spines and controls spine morphology and plasticity. Here, we report that microtubules (MTs) are present in spines and that shRNA knockdown of the MT plus-end-binding protein EB3 significantly reduces spine formation. Furthermore, stabilization and inhibition of MTs by low doses of taxol and nocodazole enhance and impair spine formation elicited by BDNF (brain-derived neurotrophic factor), respectively. Therefore, MTs play an important role in the control and regulation of dendritic spine development and plasticity.
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