期刊
JOURNAL OF NEUROSCIENCE
卷 28, 期 48, 页码 12864-12867出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2413-08.2008
关键词
calcium-sensitive adenylyl cyclase; anterior cingulate cortex; remote memory; contextual fear conditioning; memory maintenance; memory extinction
资金
- National Institutes of Health [NS20498, MH073601]
Although molecular mechanisms for hippocampus-dependent memory have been extensively studied, much less is known about signaling events important for remote memory. Here we report that mice lacking type 1 adenylyl cyclase (AC1) are able to establish and retrieve remote contextual memory but unable to sustain it as long as wild-type mice. Interestingly, mice overexpressing AC1 show superior remote contextual memory even though they exhibit normal hippocampus-dependent contextual memory. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory.
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