White-Matter Connectivity and Methylphenidate-Induced Changes in Attentional Performance According to α2A-Adrenergic Receptor Gene Polymorphisms in Korean Children With Attention-Deficit Hyperactivity Disorder

The authors examined the association between the MspI C/G and DraI C/T genotypes of the alpha(2A)-adrenergic receptor gene and white-matter connectivity and attentional performance before and after medication in 53 children with attention-deficit hyperactivity disorder. Subjects who carried the T allele at the DraI polymorphism showed fewer changes in the mean commission error scores after 8 weeks of medication and decreased fractional anisotropy (FA) values in the right middle frontal cortex than subjects without the T allele. Subjects with the C allele at the MspI polymorphism showed decreased FA values in the right postcentral gyrus than subjects without.