期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 112, 期 11, 页码 3001-3011出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00844.2013
关键词
cortex; high-gamma; model; oscillations
资金
- National Institute of Neurological Disorders and Stroke [NS-40596]
- Kosciuszko Foundation
High-gamma activity, ranging in frequency between similar to 60 Hz and 200 Hz, has been observed in local field potential, electrocorticography, EEG and magnetoencephalography signals during cortical activation, in a variety of functional brain systems. The origin of these signals is yet unknown. Using computational modeling, we show that a cortical network model receiving thalamic input generates high-gamma responses comparable to those observed in local field potential recorded in monkey somatosensory cortex during vibrotactile stimulation. These high-gamma oscillations appear to be mediated mostly by an excited population of inhibitory fast-spiking interneurons firing at high-gamma frequencies and pacing excitatory regular-spiking pyramidal cells, which fire at lower rates but in phase with the population rhythm. The physiological correlates of high-gamma activity, in this model of local cortical circuits, appear to be similar to those proposed for hippocampal ripples generated by subsets of interneurons that regulate the discharge of principal cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据