期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 110, 期 11, 页码 2648-2660出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00370.2013
关键词
development; eye movement; neurophysiology; persistent activity; principal sulcus
资金
- National Institute of Mental Health [R33 MH-86946]
- Tab Williams Family Endowment Fund
- National Center for Research Resources (NCRR) of the National Institutes of Health (NIH) [P51 RR-000167]
- Research Facilities Improvement Program [RR-15459-01, RR-020141-01]
The dorsolateral prefrontal cortex matures late into adolescence or early adulthood. This pattern of maturation mirrors working memory abilities, which continue to improve into adulthood. However, the nature of the changes that prefrontal neuronal activity undergoes during this process is poorly understood. We investigated behavioral performance and neural activity in working memory tasks around the time of puberty, a developmental event associated with the release of sex hormones and significant neurological change. The developmental stages of male rhesus monkeys were evaluated with a series of morphometric, hormonal, and radiographic measures. Peripubertal monkeys were trained to perform an oculomotor delayed response task and a variation of this task involving a distractor stimulus. We found that the peripubertal monkeys tended to abort a relatively large fraction of trials, and these were associated with low levels of task-related neuronal activity. However, for completed trials, accuracy in the delayed saccade task was high and the appearance of a distractor stimulus did not impact performance significantly. In correct trials delay period activity was robust and was not eliminated by the presentation of a distracting stimulus, whereas in trials that resulted in errors the sustained cue-related activity was significantly weaker. Our results show that in peripubertal monkeys the prefrontal cortex is capable of generating robust persistent activity in the delay periods of working memory tasks, although in general it may be more prone to stochastic failure than in adults.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据