4.4 Article

Responses to pulsatile subretinal electric stimulation: effects of amplitude and duration

期刊

JOURNAL OF NEUROPHYSIOLOGY
卷 109, 期 7, 页码 1954-1968

出版社

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00293.2012

关键词

electrical stimulation; patch-clamp cell recordings; ganglion cells; subretinal implant; retinal prosthesis

资金

  1. Veterans Administration [MR1I01RX000350-01A1]
  2. National Eye Institute [R01-EY019967]

向作者/读者索取更多资源

Lee SW, Eddington DK, Fried SI. Responses to pulsatile subretinal electric stimulation: effects of amplitude and duration. J Neurophysiol 109: 1954-1968, 2013. First published January 23, 2013; doi:10.1152/jn.00293.2012.-In working to improve the quality of visual percepts elicited by retinal prosthetics, considerable effort has been made to understand how retinal neurons respond to electric stimulation. Whereas responses arising from direct activation of retinal ganglion cells have been well studied, responses arising through indirect activation (e. g., secondary to activation of bipolar cells) are not as well understood. Here, we used cell-attached, patch-clamp recordings to measure the responses of rabbit ganglion cells in vitro to a wide range of stimulus-pulse parameters (amplitudes: 0-100 mu A; durations: 0.1-50 ms), applied to a 400-mu m-diameter, subretinal-stimulating electrode. The indirect responses generally consisted of multiple action potentials that were clustered into bursts, although the latency and number of spikes within a burst were highly variable. When different parameter pairs representing identical charge levels were compared, the shortest pulse durations generally elicited the most spikes. In addition, latencies were shortest, and jitter was lowest for short pulses. These findings suggest that short pulses are optimum for activation of presynaptic neurons, and therefore, short pulses are more effective for both direct as well as indirect activation.

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