期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 101, 期 4, 页码 1742-1748出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.91311.2008
关键词
-
资金
- National Institute of Dental and Craniofacial Research [NS DE-13685]
Sawyer CM, Iodi Carstens M, Simons CT, Slack J, McCluskey TS, Furrer S, Carstens E. Activation of lumbar spinal wide-dynamic range neurons by a sanshool derivative. J Neurophysiol 101: 1742-1748, 2009. First published January 21, 2009; doi: 10.1152/jn.91311.2008. The enigmatic sensation of tingle involves the activation of primary sensory neurons by hydroxy-alpha-sanshool, a tingly agent in Szechuan peppers, by inhibiting two-pore potassium channels. Central mechanisms mediating tingle sensation are unknown. We investigated whether a stable derivative of sanshool-isobutylalkenyl amide (IBA)-excites wide-dynamic range (WDR) spinal neurons that participate in transmission of chemesthetic information from the skin. In anesthetized rats, the majority of WDR and low-threshold units responded to intradermal injection of IBA in a dose-related manner over a >5-min time course and exhibited tachyphylaxis at higher concentrations (1 and 10%). Almost all WDR and low-threshold units additionally responded to the pungent agents mustard oil (allyl isothiocyanate) and/or capsaicin, prompting reclassification of the low-threshold cells as WDR. The results are discussed in terms of the functional role of WDR neurons in mediating tingle sensation.
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