期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 100, 期 4, 页码 2441-2452出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00924.2007
关键词
-
资金
- Center for Circuit & System Solutions/MARCO Focus Center
- National Defense Science and Engineering Graduate Fellowships
- National Science Foundation
- Christopher Reeve Paralysis Foundation
- Stanford University
- Stanford-National Institutes of Health Medical Scientist Training Program
- Burroughs Wellcome Fund Career Award in the Biomedical Sciences
- Center for Integrated Systems at Stanford
- Office of Naval Research (Adaptive Neural Systems)
- Sloan Foundation
- Whitaker Foundation
Neural prosthetic interfaces use neural activity related to the planning and perimovement epochs of arm reaching to afford brain-directed control of external devices. Previous research has primarily centered on accurately decoding movement intention from either plan or perimovement activity, but has assumed that temporal boundaries between these epochs are known to the decoding system. In this work, we develop a technique to automatically differentiate between baseline, plan, and perimovement epochs of neural activity. Specifically, we use a generative model of neural activity to capture how neural activity varies between these three epochs. Our approach is based on a hidden Markov model (HMM), in which the latent variable ( state) corresponds to the epoch of neural activity, coupled with a state-dependent Poisson firing model. Using an HMM, we demonstrate that the time of transition from baseline to plan epochs, a transition in neural activity that is not accompanied by any external behavior changes, can be detected using a threshold on the a posteriori HMM state probabilities. Following detection of the plan epoch, we show that the intended target of a center-out movement can be detected about as accurately as that by a maximum-likelihood estimator using a window of known plan activity. In addition, we demonstrate that our HMM can detect transitions in neural activity corresponding to targets not found in training data. Thus the HMM technique for automatically detecting transitions between epochs of neural activity enables prosthetic interfaces that can operate autonomously.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据