期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 100, 期 4, 页码 1897-1908出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.90346.2008
关键词
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资金
- National Institutes of Health [R37 AG-08796, 5T32-MH-67564, P50 NS-047085]
Experiencedependent modification in the electrical properties of central neurons is a form of intrinsic plasticity that occurs during development and has been observed following behavioral learning. We report a novel form of intrinsic plasticity in hippocampal CA1 pyramidal neurons mediated by the K(V)7/KCNQ and Ca(V)1/L-type Ca2+ channels. Enhancing Ca2+ influx with a conditioning spike train (30 Hz, 3 s) potentiated the K(V)7/KCNQ channel function and led to a long-lasting, activity-dependent increase in spike frequency adaptation - a gradual reduction in the firing frequency in response to sustained excitation. These effects were abolished by specific blockers for Ca(V)1/L-type Ca2+ channels, K(V)7/KCNQ channels, and protein kinase A (PKA). Considering the widespread expression of these two channel types, the influence of Ca2+ influx and subsequent activation of PKA on K(V)7/KCNQ channels may represent a generalized principle in fine tuning the output of central neurons that promotes stability in firing - an example of homeostatic regulation of intrinsic membrane excitability.
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