期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 73, 期 7, 页码 640-657出版社
OXFORD UNIV PRESS INC
DOI: 10.1097/NEN.0000000000000091
关键词
Alzheimer disease; Amyotrophic lateral sclerosis; Bioenergetics; Metabolomics; Oxidative stress; Parkinson disease; Selective neuronal vulnerability
资金
- Spanish Ministry of Science and Innovation [BFU2009-11879/BFI]
- Spanish Ministry of Health [PI11/1532, PI13/00584]
- Autonomous Government of Catalonia [2009SGR735]
- La Marato de TV3 Foundation
- COST Action of the European Union [B35]
- European Commission [278486: DEVELAGE]
Neurons in the mature human central nervous system(CNS) perform a wide range of motor, sensory, regulatory, behavioral, and cognitive functions. Such diverse functional output requires a great diversity of CNS neuronal and non-neuronal populations. Metabolomics encompasses the study of the complete set of metabolites/low-molecular-weight intermediates (metabolome), which are context-dependent and vary according to the physiology, developmental state, or pathologic state of the cell, tissue, organ, or organism. Therefore, the use of metabolomics can help to unravel the diversityVand to disclose the specificity-of metabolic traits and their alterations in the brain and in fluids such as cerebrospinal fluid and plasma, thus helping to uncover potential biomarkers of aging and neurodegenerative diseases. Here, we review the current applications of metabolomics in studies of CNS aging and certain age-related neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis. Neurometabolomics will increase knowledge of the physiologic and pathologic functions of neural cells and will place the concept of selective neuronal vulnerability in a metabolic context.
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