期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 72, 期 1, 页码 53-60出版社
OXFORD UNIV PRESS INC
DOI: 10.1097/NEN.0b013e31827c5710
关键词
gamma-Synuclein; ChAT activity; Dementia with Lewy body; Occipital lobe; SNAP-25; Synaptic proteins; Synaptophysin
资金
- PPP Grant
- Alzheimer Society
- UK NIHR Biomedical Research Centre for Ageing and Age-Related Disease Award
- Canadian Institutes of Health Research
- Alzheimers Research UK [ART-ESG2010-6] Funding Source: researchfish
- Medical Research Council [G0700718B] Funding Source: researchfish
Functional neuroimaging studies have consistently reported abnormalities in the visual cortex in patients with dementia with Lewy bodies (DLB), but their neuropathologic substrates are poorly understood. We analyzed synaptic proteins and choline acetyltransferase (ChAT) in the primary (BA17) and association (BAs18/19) visual cortex in DLB and similar aged control and Alzheimer disease (AD) subjects. We found lower levels of synaptophysin, syntaxin, SNAP-25, and gamma-synuclein in DLB subjects versus both aged control (68%-78% and 27%-72% for BA17 and BAs18/19, respectively) and AD cases (54%-67% and 10%-56% for BA17 and BAs18/19, respectively). The loss in ChAT activity in DLB cases was also greater in BA17 (72% and 87% vs AD and control values, respectively) than in BAs18/19 (52% and 65% vs AD and control groups, respectively). The observed synaptic and ChAT changes in the visual cortices were not associated with tau or A-amyloid pathology in the occipital or the frontal, temporal, and parietal neocortex. However, the neocortical densities of LBs, particular those in BA17 and BAs18/19, correlated with lower synaptic and ChAT levels in these brain areas. These findings draw attention to molecular changes within the primary visual cortex in DLB and correlate with the neuroimaging findings within the occipital lobe in patients with this disorder.
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