期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 71, 期 10, 页码 882-893出版社
OXFORD UNIV PRESS INC
DOI: 10.1097/NEN.0b013e31826bf704
关键词
Gene expression; Gene promoter methylation; Immunohistochemistry; Meningioma; Molecular signature of aggressivity; Recurrence; Progression
资金
- Fundacion Sociosanitaria de Castilla-La Mancha of the Consejeria de Salud y Bienestar Social [PI-2006/29, PI10-045]
- Junta de Comunidades de Castilla-La Mancha
- Fondo de Investigaciones Sanitarias (FIS), Spain [PI08/1662, PI10/1972, RD-09/0076/00074]
- Fundacion Sociosanitaria de Castilla-La Mancha [MOV-2008 JI/2]
Meningiomas are the most common primary brain tumors; they arise from the coverings of the brain. Although meningiomas are generally benign, some are more clinically aggressive, as reflected by their histopathological features or by their unexpected recurrence. We hypothesized that recurrent histologically benign meningiomas might have genetic features in common with those showing a more aggressive histology. By comparing gene expression profiles associated with meningioma progression and recurrence in 128 tumor samples (i.e. 83 benign World Health Organization [WHO] Grade I, 37 atypical WHO Grade II, and 8 anaplastic WHO Grade III) from 121 patients, we identified a 49-gene signature of meningioma aggressivity. This signature classified the tumors into 2 groups showing different clinical and pathological behaviors. The signature was composed of genes involved in the cell cycle (TMEM30B, CKS2, and UCHL1) and other pathways previously described as being altered in meningiomas, that is, WNT (SFRP1 and SFRP4) and transforming growth factor-beta pathways (LTBP2 and LMO4). Overall, gene downregulation was observed in advanced and recurrent samples versus benign and original ones. We propose that this gene repression may be caused by gene promoter hypermethylation, as in the case of UCHL1 and SFRP1, suggesting that this epigenetic event, together with loss of specific chromosomal regions, may play an important role in meningioma progression and recurrence.
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