期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 69, 期 12, 页码 1228-1246出版社
OXFORD UNIV PRESS INC
DOI: 10.1097/NEN.0b013e3181ffe742
关键词
Chloride channel; Chloride/proton exchanger; Grey lethal; Lysosomal storage disorder; Neuronal ceroid lipofuscinosis/Batten disease
资金
- National Institutes of Health [NS41930]
- European Commission [LSHM-CT-2003-503051]
- UK Medical Research Council
- Deutsche Forschungsgemeinschaft [Je164/7, SFB 740]
- Academy of Finland [1122404]
- Batten Disease Support and Research Association
- The Batten Disease Family Association
- The Natalie Fund
The proteins ClC-6 and ClC-7 are expressed in the endosomallysosomal system. Because Clcn6-deficient mice display some features of neuronal ceroid lipofuscinosis (NCL), CLCN6 may be a candidate gene for novel forms of NCL. Using landmarks of disease progression from NCL mouse models as a guide, we examined neuropathologic alterations in the central nervous system of Clcn6(-/-), Clcn7(-/-), and gl mice. gl mice bear a mutation in Ostm1, the beta-subunit critical for Clcn7 function. Severely affected Clcn7(-/-) and gl mice have remarkably similar neuropathologic phenotypes, with pronounced reactive changes and neuron loss in the thalamocortical system, similar to findings in early-onset forms of NCL. In contrast, Clcn6(-/-) mice display slowly progressive, milder neuropathologic features with very little thalamic involvement or microglial activation. These findings detail for the first time the markedly different neuropathologic consequences of mutations in these two CLC genes. Clcn7(-/-) and gl mice bear a close resemblance to the progressive neuropathologic phenotypes of early onset forms of NCL, whereas the distinct phenotype of Clcn6-deficient mice suggests that this gene could be a candidate for a later-onset form of mild neurologic dysfunction with some NCL-like features.
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