期刊
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
卷 68, 期 5, 页码 482-488出版社
OXFORD UNIV PRESS INC
DOI: 10.1097/NEN.0b013e3181a13fca
关键词
Folliculostellate; Glioma; Immunohistochemistry; Infundibulum; Neurohypophysis; Pituicyte; Thyroid transcription factor 1
资金
- Department of Pathology and Laboratory Medicine
- Hospital of the University of Pennsylvania
Pituicytomas are rare low-grade gliomas of the neurohypophysis. Their morphology and variable immunophenotype have led to speculation that they arise from pituicytes. Given the role of thyroid transcription factor 1 (TTF-1) in the developing rodent infundibulum and its expression in the adult rat neurohypophysis, we speculated that TTF-1 would be a marker of human pituicytes. Using immunohistochemistry, we found that TTF-1 is strongly expressed in fetal and adult human pituicytes. A survey of sellar masses demonstrated specific TTF-1 expression in pituicytomas (n = 3). atypical pituicytomas (n = 2), and granular cell tumors (n = 4), indicating a common pituicyte lineage. TTF-1 expression in spindle cell oncocytomas (n = 8) is less easily explained but invites speculation. Our observations may have implications for the classification of these rare sellar neoplasms, all the while acknowledging the morphological diversity of pituicyte-related neoplasms.
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