期刊
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
卷 84, 期 8, 页码 859-861出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp-2012-304670
关键词
-
资金
- Baxter Healthcare BV, The Netherlands
- Netherlands Organization for Health Research and Development [907-00-111]
Objective To determine the variability of serum IgG in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods All 25 CIDP patients had active but stable disease and were treated with individually optimised fixed dose IVIg regimens. IgG was measured by turbidimetry and variability was defined as coefficient of variation (CV). Results The intra-patient variability of the pre-treatment IgG levels, post-treatment levels and increase in serum IgG shortly after IVIg (AlgG) was low (mean CV=3%, 4%, 10%). The inter-patient variability between patients treated with the same dose and interval was low in pre-treatment, post-treatment and AlgG level (mean CV=13%, 11%, 20%). The AlgG levels were associated with IVIg dosage (rs=0.78, p<0.001). Conclusions Clinically stable CIDP patients show a steady-state in serum IgG after serial IVIg infusions. The low intra- and inter-patient variability in IgG may indicate that constant levels are required to reach this stability.
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