期刊
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
卷 79, 期 8, 页码 955-958出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jnnp.2007.138685
关键词
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资金
- Multiple Sclerosis Society [748] Funding Source: Medline
Background: Cognitive impairment is common in multiple sclerosis ( MS) and adds significantly to the burden of the disease. The ability to predict future cognitive impairment from imaging obtained at disease onset has not been investigated. Methods: 62 patients imaged within 3 months of a clinically isolated syndrome were assessed neuropsychologically 7 years later. Baseline and periodic MRI measures of lesions, atrophy and normal-appearing white and grey matter were regressed against neuropsychological scores to explore the best predictors of cognitive outcome. Results: 28 patients had developed clinically definite MS at follow-up and a further nine met revised McDonald criteria for MS. Deficits in speed of information processing and executive function were the most common abnormalities. Poor performance correlated with high anxiety ratings. Baseline T-1 lesion metrics predicted executive deficits, and new T-2 lesions at the 3-month follow-up predicted slowed information processing. An increase in myo-inositol concentration in normal- appearing white matter over the first 3 years was associated with poor executive function. Conclusions: MRI variables obtained at the onset of a clinically isolated syndrome can predict future development of cognitive abnormalities. Our findings may have implications in monitoring and treating patients.
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