期刊
JOURNAL OF NEUROLOGY
卷 261, 期 1, 页码 196-206出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-013-7174-x
关键词
Higher-level gait disorders; Gait initiation; MRI; Mesencephalic locomotor region
资金
- Institut National de la Recherche Medicale
- 'Institut du Cerveau et de la Moelle Epiniere (ICM) Foundation
- Regie Autonome des Transports Parisiens' (RATP)
- Agence Nationale de la Recherche Programme for Young Researchers [R05121DS]
- [ANR-06NEURO-006-01]
The pathophysiology of gait and balance disorders in elderly people with 'higher level gait disorders' (HLGD) is poorly understood. In this study, we aimed to identify the brain networks involved in this disorder. Standardised clinical scores, biomechanical parameters of gait initiation and brain imaging data, including deep white matter lesions (DWML) and brain voxel-based morphometry analyses, were assessed in 20 HLGD patients in comparison to 20 age-matched controls. In comparison to controls, HLGD patients presented a near-normal preparatory phase of gait initiation, but a severe alteration of both locomotor and postural parameters of first-step execution, which was related to 'axial' hypokinetic-rigid signs. HLGD patients showed a significant grey matter reduction in the mesencephalic locomotor region (MLR) and the left primary motor cortex. This midbrain atrophy was related to the severity of clinical and neurophysiologically determined balance deficits. HLGD patients also showed a reduction in speed of gait, related to 'appendicular' hypokinetic-rigid signs and frontal-lobe-like cognitive deficits. These last two symptoms were correlated with the severity of DWML, found in 12/20 HLGD patients. In conclusion, these data suggest that the gait and balance deficits in HLGD mainly result from the lesion or
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