期刊
JOURNAL OF NEUROLOGY
卷 259, 期 6, 页码 1199-1205出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-011-6337-x
关键词
Multiple sclerosis; Positron emission tomography; Microglia; Copolymer 1; Immunology; PK11195
资金
- TEVA Neuroscience
- Nancy Davis Foundation for Multiple Sclerosis
- Novartis
- Biogen Idec.
- Biogen-IDEC
- Teva
- EMD-Serono
- Vertex
- Genentech
- Abbott
- Bayer
Activated microglia are thought to be an important contributor to tissue damage in multiple sclerosis (MS). The level of microglial activation can be measured non-invasively using [C-11]-R-PK11195, a radiopharmaceutical for positron emission tomography (PET). Prior studies have identified abnormalities in the level of [C-11]-R-PK11195 uptake in patients with MS, but treatment effects have not been evaluated. Nine previously untreated relapsing-remitting MS patients underwent PET and magnetic resonance imaging of the brain at baseline and after 1 year of treatment with glatiramer acetate. Parametric maps of [C-11]-R-PK11195 uptake were obtained for baseline and post-treatment PET scans, and the change in [C-11]-R-PK11195 uptake pre- to post-treatment was evaluated across the whole brain. Region-of-interest analysis was also applied to selected subregions. Whole brain [C-11]-R-PK11195 binding potential per unit volume decreased 3.17% (95% CI: -0.74, -5.53%) between baseline and 1 year (p = 0.018). A significant decrease was noted in cortical gray matter and cerebral white matter, and a trend towards decreased uptake was seen in the putamen and thalamus. The results are consistent with a reduction in inflammation due to treatment with glatiramer acetate, though a larger controlled study would be required to prove that association. Future research will focus on whether the level of baseline microglial activation predicts future tissue damage in MS and whether [C-11]-R-PK11195 uptake in cortical gray matter correlates with cortical lesion load.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据