期刊
JOURNAL OF NEUROLOGY
卷 255, 期 8, 页码 1215-1219出版社
DR DIETRICH STEINKOPFF VERLAG
DOI: 10.1007/s00415-008-0878-7
关键词
multiple sclerosis; genetics; outcome
资金
- Multiple Sclerosis Society of Canada Scientific Research Foundation
- Medical Research Council of the United Kingdom
- Michael Smith Foundation
Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. As little is conclusively known about MS disease mechanisms, we have selected a variety of candidate genes that may influence the prognosis of the disease based on their function. A cohort of sporadic MS cases, taken from opposite extremes of the putative distribution of long-term outcome using the most stringent clinical criteria to date, was used to determine the role of on MS disease severity. The MS cases selected represent the prognostic best 5% (benign MS) and worst 5% (malignant MS) of cases in terms of clinical outcome assessed by the EDSS. Genotyping the two sets of MS patients (112 benign and 51 malignant) and a replication cohort from Sardinia provided no evidence to suggest that the genes selected have any outcome modifying activity, although small effects of these genes cannot be ruled out.
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