期刊
JOURNAL OF NEUROINTERVENTIONAL SURGERY
卷 3, 期 2, 页码 131-136出版社
B M J PUBLISHING GROUP
DOI: 10.1136/jnis.2010.004390
关键词
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资金
- Micrus Endovascular
- National Institutes of Health
- Guerbet
- Micrus Endovascular Inc
- Codman Neurovascular
- Boston Scientific
- eV3
- Philips Healthcare
- NeuroVasx Inc
- Concentric Medical
- Abbott Vascular
- Microvention
- Brain Aneurysm Foundation
- Erika Keeney Foundation
Objective To investigate the impact of coil design on the distribution of the coil mass in a controlled in vitro experiment. A secondary objective was to study the relationship between angiographic occlusion, packing density and coil mass uniformity. Methods Seven silicon side wall aneurysm models were embolized in each arm with a different coil design under fluoroscopic guidance. Packing density calculations and scoring of the angiographic occlusion were made. The models were embedded in epoxy and sectioned through the aneurysm neck and the dome. The sections were imaged and processed to derive the fractional surface area of coil material over the coil free area, a quantitative endpoint representing the percentage of the given region of interest consumed by coils. The SD of the surface area fractions is inversely proportional to the uniformity of coil distribution. Results The novel triangular primary wind design of the Deltapaq achieved a more homogenous distribution of coils within the aneurysm dome compared with the helical and complex microcoil systems (p=0.018). The packing density achieved by the Deltapaq (39.1+/-1.6%) was significantly higher than the complex (35.2+/-2.8%) and the helical (32.2+/-3.3%) coils. Angiographically, aneurysms coiled by the Deltapaq were more likely to obtain a Raymond score of class I. Conclusion Evaluation of emerging coil technologies with respect to treatment durability may be well served by an assessment of their uniformity of distribution within an aneurysm in addition of the traditional packing density and angiographic occlusion scoring methods.
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