期刊
JOURNAL OF NEUROINFLAMMATION
卷 11, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1742-2094-11-52
关键词
LRRK2; Neuroinflammation; Microglia; Neurodegeneration; Parkinson's disease; Dopaminergic neurons
资金
- Michael J. Fox Foundation for Parkinson's Disease
- Italian Ministry of University and Research (Rientro dei Cervelli, lncentivazione alla mobilita di studiosi stranieri e italiani residenti all'estero)
- CARIPLO Foundation [2011-0540]
- Telethon - Italy [GGP12237]
It is now well established that chronic inflammation is a prominent feature of several neurodegenerative disorders including Parkinson's disease (PD). Growing evidence indicates that neuroinflammation can contribute greatly to dopaminergic neuron degeneration and progression of the disease. Recent literature highlights that leucine-rich repeat kinase 2 (LRRK2), a kinase mutated in both autosomal-dominantly inherited and sporadic PD cases, modulates inflammation in response to different pathological stimuli. In this review, we outline the state of the art of LRRK2 functions in microglia cells and in neuroinflammation. Furthermore, we discuss the potential role of LRRK2 in cytoskeleton remodeling and vesicle trafficking in microglia cells under physiological and pathological conditions. We also hypothesize that LRRK2 mutations might sensitize microglia cells toward a pro-inflammatory state, which in turn results in exacerbated inflammation with consequent neurodegeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据