期刊
JOURNAL OF NEUROINFLAMMATION
卷 10, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1742-2094-10-133
关键词
A disintegrin and metalloproteinase with thrombospondin motifs; Proteoglycanases; Stroke; Spinal cord injury; Chondroitin sulfate proteoglycan; Synaptic plasticity; Inflammation; Angiogenesis; Neurorepair
资金
- University of Eastern Finland
- ERANET-Neuron research program
ADAMTS- 1, - 4, - 5 and - 9 belong to 'a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)' family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans. They have been extensively investigated for their involvement in inflammation-induced osteoarthritis, and a growing body of evidence indicates that they may be of key importance in the physiological and pathological central nervous system (CNS). In this review, we discuss the deregulated expression of ADAMTS proteoglycanases during acute CNS injuries, such as stroke and spinal cord injury. Then, we provide new insights on ADAMTS proteoglycanases mediating synaptic plasticity, neurorepair, angiogenesis and inflammation mechanisms. Altogether, this review allows us to propose that ADAMTS proteoglycanases may be original therapeutic targets for CNS injuries.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据