Neurotensin is increased in serum of young children with autistic disorder

Autism spectrum disorders (ASD) are a group of pervasive neurodevelopmental disorders diagnosed in early childhood. They are associated with a set of core symptoms that include disabilities in social interaction skills, verbal and non-verbal communication, as well as repetitive and stereotypic behaviors. There is no definite pathogenetic mechanism or diagnostic tests. Many children with ASD also have allergic-like symptoms, but test negative implying mast cell activation by non-allergic triggers. We measured by Milliplex arrays serum levels of 3 neuropeptides that could stimulate mast cells in children with autistic disorder (n = 19; 16 males and 3 females; mean age 3.0 +/- 0.4 years) and healthy, unrelated controls (n = 16; 13 males and 3 females; mean age 3 +/- 1.2 years). Only neurotensin (NT) was significantly increased from 60.5 +/- 6.0 pg/ml in controls to 105.6 +/- 12.4 pg/ml in autistic disorder (p = 0.004). There was no statistically significant difference in the serum levels of beta-endorphin or substance P (SP). NT could stimulate immune cells, especially mast cells, and/or have direct effects on brain inflammation and ASD.