期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 325, 期 -, 页码 1-9出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.09.009
关键词
Experimental autoimmune encephalomyelitis; Spinal cord homogenate; Optic neuritis; Visual evoked potentials
资金
- Merck
- Italian ministry of Education, University and Research (cluster project IVASCOMAR) [CTN01_0177_165430]
Dark-Agouti rats were immunized with spinal cord homogenate to develop Experimental Autoimmune Encephalomyelitis, a model of multiple sclerosis. We assessed motor signs and recorded VEPs for five or eight weeks with epidural or epidermal electrodes, respectively, with final histopathology of optic nerves (ONs). Injected rats exhibited motor deficits a week after immunization. VEP delays arose from the 2nd to the 5th week, when a recovery occurred in epidermal-recorded rats. ON damage appeared in epidural-, but not in epidermal-recorded rats, probably due to a remyelination process. VEP could be exploited as neurophysiological marker to test novel treatments against neurodegeneration involving ONs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据