期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 324, 期 -, 页码 149-156出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.08.015
关键词
Stress granules; Interferon gamma; Heterogeneous nuclear ribonucleoprotein A1; hnRNP A1; Multiple sclerosis; Neurodegeneration
资金
- Office of the Saskatchewan Multiple Sclerosis Clinical Research Chair, University of Saskatchewan
- Saskatchewan Health Research Foundation [4244]
- Saskatoon City Hospital Foundation, Saskatoon, Saskatchewan, Canada
Dysfunction of the RNA binding protein (RBP) heterogeneous nuclear ribonuclear protein A1 (hnRNP A1) has been shown to contribute to the pathogenesis of neurodegenerative diseases, but its involvement in multiple sclerosis (MS) is largely unknown. In a neuronal cell line, interferon-y caused hnRNP A1 nucleocytoplasmic mislocalization; colocalization of hnRNP A1 in stress granules (SGs); and inhibition of translation. Neurons in the brain of a MS patient showed pathogenic RBP dysfunction, including nuclear depletion of hnRNP A1, its mislocalization to the cytoplasm, and its colocalization in SGs. These data indicate a role for dysfunctional hnRNP A1 in the pathogenesis of MS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据