期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 274, 期 1-2, 页码 1-13出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2014.07.012
关键词
Neuroinflammation; Neurodegenerative disorders; Microglia; T-cells; Neo-antigens; Blood-brain barrier
资金
- FONDECYT [1130271]
- CONICYT [PFB-16]
- Universidad San Sebastian [2011-0001-R]
- Universidad Andres Bello
- CONICYT graduated fellowship
Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders. (C) 2014 Elsevier B.V. All rights reserved.
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