期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 277, 期 1-2, 页码 153-159出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2014.10.005
关键词
Cerebrospinal fluid; Cytokines; Magnetic resonance imaging; Multiple sclerosis
In this cross-sectional study, we wanted to identify key cytokines characteristic of different stages of multiple sclerosis (MS). To this end, cerebrospinal fluid from patients with MS was investigated with a multiplexed fluorescent bead-based immunoassay. In total 43 cytokines were assessed and related to clinical and imaging data. Increased levels of CCL22, CXCL10 and sCD40L characterized relapsing-remitting MS patients with the presence of gadolinium-enhancing lesions; decreased CCL2 and increased CXCL1 and CCL5 were typical of relapsing-remitting MS patients irrespectively of the presence of gadolinium-enhancing lesions. These homogenous patterns of cytokine activation do not conform to conventional Th1/Th2/Th17 responses. (C) 2014 Elsevier B.V. All rights reserved.
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