期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 274, 期 1-2, 页码 215-224出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2014.07.015
关键词
Stroke; Interleukin-6; Outcome; Meta-analysis; Post-stroke infection; Individual participant data analysis
资金
- Instituto de Salud Carlos III [CM/00265]
- Vall Hebron Institute of Research
- Neurovascular Research Laboratory takes part in the Spanish stroke research network INVICTUS [RD12/0014/0005]
- FIS [11/0176]
- MRC [G0902303] Funding Source: UKRI
- Chief Scientist Office [CAF/06/30] Funding Source: researchfish
- Medical Research Council [G0902303] Funding Source: researchfish
We aimed to quantify the association of blood interleuldn-6 (IL-6) concentrations with poor outcome after stroke and its added predictive value over clinical information. Meta-analysis of 24 studies confirmed this association with a weighted mean difference of 3.443 (1.592-5.294) pg/mL, despite high heterogeneity and publication bias. Individual participant data including 4112 stroke patients showed standardized IL-6 levels in the 4th quartile were independently associated with poor outcome (OR = 2.346 (1.814-3.033), p <0.0001). However, the additional predictive value of IL-6 was moderate (IDI = 1.5%, NRI = 5.35%). Overall these results indicate an unlikely translation of IL-6 into clinical practice for this purpose. (C) 2014 Elsevier B.V. All rights reserved.
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