期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 274, 期 1-2, 页码 174-179出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2014.06.024
关键词
Multiple sclerosis; Oligoclonal bands; HLA; Killer cell immunoglobulin-like receptors
资金
- Research Council of Norway [196776]
- Oslo MS Society
- Odd Fellow MS Foundation
- Knut and Alice Wallenberg Foundation
- Stockholm County Council
- Swedish Research Council
- Danish MS Society
- Danish Council for Strategic Research
Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n = 3876). Specific KIR ligands were associated with patients when compared to controls (n = 3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated. (C) 2014 Elsevier B.V. All rights reserved.
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