期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 274, 期 1-2, 页码 202-208出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2014.07.006
关键词
Muscle biopsy; Autoantibodies; RNA immunoprecipitation; Inflammatory myopathies; Necrotizing myopathy; Signal recognition particle
资金
- Japanese Ministry of Education, Science, Sports and Culture [26461298]
- Health and Labour Sciences Research Grant on Intractable Diseases (Neuroimmunological Diseases) Ministry of Health, Labour and Welfare of Japan
- Intramural Research Grants for Neurological and Psychiatric Disorders of NCNP [23-5, 23-4]
- MEXT [24390227]
- [24659437]
- Grants-in-Aid for Scientific Research [24390227, 26461298] Funding Source: KAKEN
Of 207 adult patients with idiopathic inflammatory myopathies, detection of autoantibodies by RNA immunoprecipitation showed that 99 patients (48%) were antibody-positive. We divided these 99 into five subgroups: anti-signal recognition particle (SRP), anti-aminoacyl transfer RNA synthetase, anti-Ku, anti-U1RNP, and anti-SSA/B. Younger age at onset, severe weakness, muscle atrophy, elevated creatine kinase, and necrosis in muscle fibers without inflammatory cell infiltration were found significantly more frequently among the patients with anti-SRP antibodies (n = 41) compared to the antibody-negative patients (n = 108). Autoantibody detection by RNA immunoprecipitation can provide useful information associated with clinical and histological findings. (C) 2014 Elsevier B.V. All rights reserved.
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