期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 266, 期 1-2, 页码 12-23出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2013.10.014
关键词
Multiple sclerosis; MicroRNA; Exosomes; Myelin; Dendritic cell; Demyelination
资金
- National Center for Advancing Translational Sciences from the Director's Office Common Fund [1 UH 2 TR000918]
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1 TR000430]
- National Institute of Neurological Disorders and Stroke [NS-19108]
- National Institute of Child Health and Human Disorders [5 PO1 HD 09402]
- National Institutes of General Medicine [5T32GM007839-31]
- National Multiple Sclerosis Society [IL-0009]
- White Foundation
Dendritic cells (DCs) release exosomes with different characteristics based on stimulus. Here, we showed that DC cultures stimulated with low-level IFN gamma released exosomes (IFN gamma-DC-Exos) that contained microRNA species that can increase baseline myelination, reduce oxidative stress, and improve remyelination following acute lysolecithin-induced demyelination. Furthermore, nasally administered IFN gamma-DC-Exos increased CNS myelination in vivo. IFN gamma-DC-Exos were preferentially taken up by oligodendrocytes, suggesting that they directly impact oligodendrocytes to increase myelination. Thus, our results show great potential for use of these IFN gamma-DC-Exos as a therapeutic to promote remyelination in multiple sclerosis and dysmyelinating syndromes. (c) 2013 Elsevier B.V. All rights reserved.
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