期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 269, 期 1-2, 页码 20-27出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2014.01.013
关键词
Obesity; Inflammation; Hippocampus; Corticosterone; Glucocorticoid
资金
- National Institutes of Health [K01DK100616]
- Diabetes and Obesity Discovery Institute of Georgia Regents University
db/db mice are a model of obesity and diabetes due to their lack of functional leptin receptors, which leads to insulin resistance, elevated corticosterone levels, and persistent inflammation. Because stress-induced elevations in glucocorticoids sensitize microglia to immune challenges, we hypothesized that corticosteroids might act similarly in the diabetic brain. To test this hypothesis, db/db and wildtype mice were treated with the glucocorticoid synthesis inhibitor metyrapone every day for 2 weeks. This treatment revealed corticosterone-dependent increases in microglial number and accumulation of the pro-inflammatory cytokines interleukin Theta and tumor necrosis factor alpha in the hippocampus of db/db mice. Analysis of microglial responses to lipopolysaccharide stimulation revealed that glucocorticoids lower the threshold for release of pro-inflammatory cytokines, underscoring the role of corticosteroids as a precipitating factor for neuroinflammation in obesity and diabetes. (C) 2014 Elsevier B.V. All rights reserved.
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