期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 258, 期 1-2, 页码 32-40出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2013.02.013
关键词
Multiple sclerosis; Experimental autoimmune encephalomyelitis; Nasal drug administration; Glatiramer acetate; Cannabidiol; Neurogenesis
We investigated the efficiency of nasal drug administration as a new non-invasive treatment strategy for MS. Glatiramer Acetate (GA) and GA-Cannabidiol (CBD) combination administered in nasal delivery system (NDS) resulted in a statistically significant decrease of clinical scores and inflammatory cytokine expression in experimental autoimmune encephalomyelitis (EAE) mice. Even a suboptimal dose of Prednisolone in NDS was effective in preventing the clinical signs of the disease. Neuron regeneration was observed in the hippocampus of EAE mice treated with GA-CBD in NDS. This work shows that nasal administration improved drug efficiency and stimulates further research for a non-invasive strategy for MS. (C) 2013 Elsevier B.V. All rights reserved.
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