期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 256, 期 1-2, 页码 38-42出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2013.01.002
关键词
Alzheimer's disease; Systemic immune activation/inflammation; Monocyte/macrophage (MO); Monocyte chemoattractant protein-1 (MCP-1)
资金
- National Institutes of Health's (NIH) [U01-CA 66529]
- National Cancer Institute's West Coast AIDS and the Cancer Specimen Resource (ACSR) Consortium
- University of California, San Francisco (UCSF)
Immune activation and inflammation play significant roles in the pathogenesis of Alzheimer's disease (AD). To test whether AD patients showed systemic manifestations of inflammation, blood from 41 patients with early stages of AD and 31 aged-match elderly controls were evaluated. Cellular markers for monocyte/macrophage (MO) activation and CD8 T lymphocyte were increased in early AD patients. Expression of monocyte CCR2, the receptor for monocyte chemoattractant protein-1 (MCP-1), was decreased; however, plasma MCP-1 levels were significantly increased and were related to the degree of MO activation in AD. These findings suggest that AD pathogenesis may be influenced by systemic immunologic dysfunction and provides potential immunologic targets for therapeutic intervention. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据