期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 262, 期 1-2, 页码 19-26出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2013.05.010
关键词
Multiple sclerosis; Experimental autoimmune encephalomyelitis; Antibodies; Demyelination; Plasma exchange; Immunoadsorption
资金
- Fondazione Italiana Sclerosi Multipla (FISM-AISM) [2009/R/20]
- National Multiple Sclerosis Society New York [RG3858-A-2, RG3282-A-1]
- Ministero Italiano della Salute - Progetto Strategico
- Ministero Italiano della Salute - Grant Giovani Ricercatori
- FISM-AISM
- Deutsche Forschungsgemeinschaft [He2386/7-1]
- Krankheitsorientiertes Kompetenznetz fur Multiple Sklerose
The pathogenic role of antibodies in multiple sclerosis (MS) is still controversial. We transferred to mice with experimental autoimmune encephalomyelitis (EAE), animal model of MS, IgG antibodies purified from a MS patient presenting a dramatic clinical improvement during relapse after selective IgG removal with immunoadsorption. Passive transfer of patient's IgG exacerbated motor paralysis and increased mouse central nervous system (CNS) inflammation and demyelination. Binding of patient's IgG was demonstrated in mouse CNS, with a diffuse staining of white matter oligodendrocytes. These data support a growing body of evidence that antibodies can play an important role in the pathobiology of MS. (C) 2013 Elsevier B.V. All rights reserved.
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