期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 250, 期 1-2, 页码 1-8出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2012.05.007
关键词
Age-related hearing loss; Spiral ganglion degeneration; CD4(+) T cell; Regulatory T cell; Thymus involution; Interleukin 1 receptor type II
资金
- Ministry of Education, Science and Culture [8671994, 11671712, 18591895, 21592170]
- Millennium program of the Ministry of Education, Culture, Sports, Science and Technology
- Science Frontier program of the Ministry of Education, Culture, Sports, Science and Technology
- 21st Century Center of Excellence (CUE) program of the Ministry of Education, Culture, Sports, Science and Technology
- Katano and the Shiozaki Yasuko prizes of Kansai Medical University in Japan
- Grants-in-Aid for Scientific Research [18591895, 11671712, 21592170] Funding Source: KAKEN
We found that rejuvenation of the recipient immunity by inoculation of young CD4(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4(+) T cells and reduced age-related hearing loss and degeneration of the spiral ganglion in SAMP1 mice, a murine model of human senescence. Our studies on the relationship between age-related systemic immune dysfunctions and neurodegeneration mechanisms open up new avenues of treatment of neurosenescence, including presbycusis, for which there is no effective therapy. (c) 2012 Elsevier B.V. All rights reserved.
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