期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 243, 期 1-2, 页码 100-102出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.12.001
关键词
p75NTR neurotrophin receptor; Human skeletal muscle; Satellite cells; Inflammation
资金
- Italian Ministry for Health
- Association Francaise contre les Myopathies [13327]
- Fondazione Telethon Funding Source: Custom
The neurotrophin receptor p75NTR is a marker for human differentiation-prone muscle satellite cells and regulates myogenesis. Here, we wondered whether inflammation could modify p75NTR expression on muscle precursor cells in vitro and in vivo. In vitro experiments on human primary skeletal myoblasts demonstrated that exposure to IFN-gamma or IL-1 alpha decreased transcript and protein levels of p75NTR. Furthermore, histological investigations showed a reduction in the pool of p75NTR expressing satellite cells in inflammatory myopathy biopsies. These data suggest a link between muscle inflammation and reduction of p75NTR expression on precursor cells. (C) 2011 Elsevier B.V. All rights reserved.
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