期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 230, 期 1-2, 页码 148-152出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.10.023
关键词
Autoantibody; HLA; Myasthenia gravis; Late onset
资金
- Japanese Ministry of Health, Labour, and Welfare
Immunological characteristics of myasthenia gravis (MG) with late-onset have not been fully elucidated. We examined several autoantibodies and HLA-DRB1 genotyping in 260 Japanese MG patients. Sixty-two MG patients had thymoma. The others were divided into early-onset and late-onset groups separated by an age of 50 years. The ocular form was more frequent in late-onset compared to early-onset group. Seropositivity of anti-muscle-specific tyrosine kinase antibody was 2-3% in acetylcholine receptor-seronegative patients. HIA-DRB1 genotyping failed to detect statistical differences in specific alleles between each group and healthy controls. The immunological profiles in late-onset MG were different from early-onset in Japan. (C) 2010 Elsevier B.V. All rights reserved.
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