期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 238, 期 1-2, 页码 44-51出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.06.017
关键词
Neurodegeneration; Inflammation; Microglia density; Substantia nigra; Striatum
资金
- Instituto de Salud Carlos III of Spain [PI060781, PI060567]
- Junta de Andalucia, Proyecto de Excelencia [CVI-902]
- Ministerio de Educacion y Ciencia (MEC) of Spain
To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-alpha and iNOS was directly related to cell density, meanwhile the induction of the anti-inflammatory IL-10 was inversely related to cell density. Accordingly, in vivo assays showed that after LPS-injection, iNOS expression was more intense in substantia nigra, a brain area showing specific susceptibility to neurodegeneration after microglia activation, whereas IL-10 expression was more sustained in striatum, an area resistant to damage. These results support that microglia density is pivotal to control the balance between pro- and anti-inflammatory factors release. (C) 2011 Elsevier B.V. All rights reserved.
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