期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 234, 期 1-2, 页码 1-6出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.03.004
关键词
Multiple sclerosis; Proinflammatory cytokines; TNF-alpha; Anti-TNF-alpha
Tumor necrosis factor alpha (TNF-alpha) is a cytokine with pleiotropic actions that can be present both as a transmembrane protein and soluble cytokine (sTNF). Both ligands interact with two different receptors, TNFR1 and TNFR2, which mediate their biological effects. TNF-alpha is involved in the pathogenesis of multiple sclerosis (MS), however, administration of anti-TNF-alpha agents to MS patients has been associated with increased disease activity. Insomuch as TNFR1 mediates demyelination and TNFR2 remyelination, it could be hypothesized that anti-TNF-alpha agents Which selectively inhibit sTNF or signals from TNFR1 could be effective in treating MS. (C) 2011 Elsevier B.V. All rights reserved.
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