期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 237, 期 1-2, 页码 57-65出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.06.016
关键词
Corticotropin releasing hormone; S. pneumoniae; Neutrophils; Sepsis; Neuroimmune; Lung; Restraint stress
资金
- NIMHD NIH HHS [P20 MD006882, L60 MD002372] Funding Source: Medline
Utilizing a murine model of S. pneumoniae infection and restraint stress, we determined how corticotropin releasing hormone (CRH-R) receptors impacts disease. CRH-R1 (antalarmin) and CRH-R2 (astressin2B) antagonists were administered intraperitoneally prior to restraint stress followed by pulmonary S. pneumoniae infection. CRH-R1 inhibition is not protective against pneumococcal disease induced by stress. Conversely, CRH-R2 inhibition attenuates stress-induced bacterial growth and significantly prevented severe sepsis. Neutrophillic responses were associated with CRH receptor-specific disease outcome providing a potential cellular target for stress-induced susceptibility to the development of severe pneumococcal disease. CRH receptor-mediated effects on immune responses could prove valuable for novel therapeutics. Published by Elsevier B.V.
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