期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 232, 期 1-2, 页码 151-157出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.11.001
关键词
A model of systemic lupus erythematosus; A tolerogenic peptide; Hippocampal neurogenesis; Growth and neurotrophic factors; ERK and Akt pathways
To determine the effect of the tolerogenic peptide hCDR1 on hippocampal neurogenesis. we treated SLE-afflicted (NZBxNZW)F1 mice with hCDR1 (once a week for 10 weeks). The treatment resulted in the up-regulation of neurogenesis in the dentate gyrus and restored the NeuN immunoreactivity in brain hippocampi of the mice in association with increased gene expression of IGF-1, NGF and BDNF. Furthermore, hCDR1 treatment significantly up-regulated p-ERK and p-Akt that are suggested to be key components in mediating growth factor-induced neurogenesis. The observed effects of hCDR1 on hippocampal-neurogenesis and on associated signaling pathways suggest a potential role for hCDR1 in CNS lupus. (C) 2010 Elsevier B.V. All rights reserved.
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