期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 232, 期 1-2, 页码 83-93出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.10.014
关键词
Granulocyte colony-stimulating factor; Inflammation; Opioid peptides; Neuropathic pain; Animal model
资金
- Chang Gung Memorial Hospital [CMRPG361211]
- Graduate Institute of Clinical Medical Sciences, Chang Gung University
- National Science Console Grant, Taiwan [NSC 95-2314-B-182A-153-, NMRPG350461]
Previous studies have demonstrated that inflammatory cells produce several mediators that can effectively counteract pain. This study was designed to test the hypothesis that exogenous administration of recombinant mouse granulocyte-colony-stimulating factor (rmG-CSF) to enhance the recruitment of inflammatory cells to painful inflamed sites could attenuate pain in a chronic neuropathic pain model in mice. Our results indicate that treatment with rmG-CSF increased several cytokines and opioid peptides content; however, it did not attenuate but exacerbate neuropathic pain. Our study highlights the potent pro-inflammatory potential of G-CSF and suggests they may be targets for therapeutic intervention in chronic neuropathic pain. (C) 2010 Elsevier B.V. All rights reserved.
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