期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 239, 期 1-2, 页码 44-52出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.08.006
关键词
Multiple sclerosis; TMEV; SDR; Stress; IL-6; Neuroinflammation
资金
- NIH/NINDS [R01-NS060822]
- Research Office at TAMU
Chronic social disruption stress (SDR) exacerbates acute and chronic phase Theiler's murine encephalomyelitis virus (TMEV) infection, a mouse model of multiple sclerosis. However, the precise mechanism by which this occurs remains unknown. The present study suggests that SDR exacerbates TMEV disease course by priming virus-induced neuroinflammation. It was demonstrated that IL-1 beta mRNA expression increases following acute SDR; however, IL-6 mRNA expression, but not IL-1 beta, is upregulated in response to chronic SDR. Furthermore, this study demonstrated SDR prior to infection increases infection related central IL-6 and IL-1 beta mRNA expression, and administration of IL-6 neutralizing antibody during SDR reverses this increase in neuroinflammation. (C) 2011 Elsevier BM. All rights reserved.
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