期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 235, 期 1-2, 页码 27-32出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.03.007
关键词
Aquaporin-4; Devic's syndrome; NMO; Lymphocytes; T cells
资金
- Guthy Jackson Charitable Foundation
- National Institutes of Health [EY13574, DK35124]
- Oxford NIHR Biomedical Research Centre
We reported recently that intracerebral administration of NMO-IgG with human complement produces neuromyelitis optica (NMO) lesions in mice. We examined the role of T cells in the formation of NMO lesions by comparing brain histopathology in wildtype and nude mice. Brains were co-injected with IgG from NMO patients and human complement. At 24 h and 5 days, wildtype vs. nude mouse brains had comparable inflammation (CD45 immunoreactivity), loss of myelin (Luxol Fast Blue staining) and loss of AQP4 immunoreactivity. We conclude that T cells are not required for the formation of NMO lesions in this mouse model. (C) 2011 Elsevier B.V. All rights reserved.
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