期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 222, 期 1-2, 页码 29-39出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.02.018
关键词
Cytokine; Dexamethasone; Systemic inflammation; Motor behaviour
资金
- Pfizer Inc.
- Rene Baron Foundation
- Agencia Nacional de Promocion Cientifica y Tecnologica
- PIP-CONICET
- YPF foundation
Neuroinflammation has been proposed as an important component of Parkinson's Disease (PD) aetiology and/or progression. However, the inflammatory components and the mechanisms underlying their effects are only partially known. By injecting an adenovirus expressing IL-1 in the striatum, we provoked progressive neurodegeneration of dopaminergic cells in the substantia nigra, motor symptoms and microglial activation. All these effects were attenuated by an anti-inflammatory treatment. Interestingly, peripheral inflammatory stimuli exacerbated IL-1 beta induced neurodegeneration and the central inflammatory reaction. These data provide evidence that central, chronic IL-1 beta expression can trigger and systemic IL-1 beta exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD. (C) 2010 Elsevier B.V. All rights reserved.
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