期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 227, 期 1-2, 页码 185-189出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2010.07.013
关键词
Mesenchymal stem cells; Autologous; Intrathecal; Multiple sclerosis; Magnetic resonance imaging; Optical coherence tomography; Expanded disability status scale
资金
- Azem and Saadeh
We explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells (BM-MSCs) in 10 patients with advanced multiple sclerosis (MS). Patients were assessed at 3,6 and 12 months. Assessment at 3-6 months revealed Expanded Disability Scale Score (EDSS) improvement in 5/7, stabilization in 1/7, and worsening in 1/7 patients. MRI at 3 months revealed new or enlarging lesions in 5/7 and Gadolinium (Gd+) enhancing lesions in 3/7 patients. Vision and low contrast sensitivity testing at 3 months showed improvement in 5/6 and worsening in 1/6 patients. Early results show hints of clinical but not radiological efficacy and evidence of safety with no serious adverse events. (c) 2010 Elsevier B.V. All rights reserved.
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