期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 218, 期 1-2, 页码 73-82出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2009.10.008
关键词
Brain-reactive autoantibodies; Lupus; CNS lupus; Behavior; MRL mice
资金
- Arizona Biomedical Research Commission [9-073]
- NIH [1R21 AR49163-01]
Brain-reactive autoantibodies (BRAA) are hypothesized to play a role in the neuropsychiatric manifestations that accompany systemic lupus erythematosus (SLE). The present study tests the proposed relation between circulating BRAA and behavioral deficits in lupus-prone MRL/lpr mice. Two age-matched cohorts born at different times were used to test the relationship in the context of altered disease severity. Significant correlations between autoimmunity and behavior were detected in both cohorts. These results are the first to report correlations between behavior and autoantibodies to integral membrane proteins of brain. supporting the hypothesis that BRAA contribute to the behavioral dysfunction seen in lupus. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据